Human-relevant models for first-trimester biology
We build controlled systems of the maternal–fetal interface to connect clinical observations to functional biology and testable mechanisms.
From endometrial states to protocol decisions
01
Clinical inputs
Samples + timing + outcomes
Includes: Sampling context • cycle timing • protocol metadata • outcomes
02
Characterisation
Define endometrial states
Includes: Histology • transcriptomics • secretomics
03
Model perturbation
Womb-on-chip, measured in function
Includes: Perfusion + vascular response • invasion/attachment phenotypes • secretome shifts
04
Discovery
Protocol optimisation and therapeutic hypotheses
Includes: Prioritise adjunct choices • stratify trials • generate protocol hypotheses
Understanding the cells in our chip
Epithelial cells
Drive the hormone response
Stromal cells
Determine the implantation depth
Endothelial cells
Supply oxygen & nutrients to the tissue and growing embryo
Functional readouts aligned to early pregnancy
Tissue remodelling dynamics at the maternal–fetal interface
Vascular / endothelial responses where relevant
Secreted-factor shifts using targeted panels when informative
State stability and inducibility under hormonal and immune cues